Long before science made “materialism” fashionable, two ancient traditions—India’s Cārvāka and Greece’s Epicureanism—dared to say that only the material world exists, that pleasure and reason, not gods or rituals, are the keys to human happiness. Yet, though they share a disbelief in the supernatural, they differ in spirit. Cārvāka celebrates life’s sensual immediacy; Epicurus refines pleasure into calm contentment. One urges us to taste life while it lasts; the other, to understand life so we can stop fearing it. Together, they remind us that meaning need not hide behind mysticism.